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Oral nicotinamide (vitamin B3) has been shown to effectively reduce the risk of developing nonmelanoma skin cancers—particularly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)—in individuals at high risk. The most robust evidence comes from a phase 3 randomized controlled trial demonstrating that nicotinamide significantly decreased the incidence of new nonmelanoma skin cancers over a 12-month period. However, it did not show benefit in preventing melanoma, and its protective effec
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