Buffalo's defense, led by new pass-rusher Nick Bosa, showed the blueprint Sunday to defeating Patrick Mahomes. Will it carry over into the postseason?

The San Francisco 49ers and New York Giants met on Sunday afternoon at MetLife Stadium. Here were some of the best plays from San Francisco's win.

Mykel Williams is feared to have suffered a potential season-ending injury in San Francisco's win over the Giants.

San Francisco 49ers rookie defensive end Mykel Williams left Sunday's game with a knee injury the team fears could be a torn ACL.

Lands on IR ...

NFL insider expects 49ers to stay active in trade market after Keion White deal originally appeared on The Sporting News. Add ...

DK Metcalf connection get the better of the Colts defense? Marcas Grant highlights 10 sleepers to consider for your fantasy ...

With the Nov. 4 trade deadline approaching, Kevin Patra plays matchmaker, identifying 11 player-team fits that make sense.

It didn't take long for the San Francisco 49ers to miss superstar defensive end Nick Bosa. The impact of his absence due to a torn ACL he suffered in Week 3 was felt immediately in the 49ers' Week 4 ...

The San Francisco 49ers have already lost linebacker Fred Warner to a long-term injury, and now they may have lost another player at the position.

The San Francisco 49ers have had some bad luck with injuries in their front seven, and they may have lost another defender against the Houston Texans.

The Kyle Shanahan era in San Francisco is defined not only by success, but by survival. Since he arrived as head coach in ...