For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

The primary cilium plays a crucial role in regulating whole-body energy metabolism, as reflected in Bardet-Biedl syndrome (BBS), where ciliary dysfunction leads to obesity due to hyperphagia and white ...

Therefore, the aim of this study was to perform an extensive multi-omic analyses on cryopreserved pre-mortem human left ventricular myocardium to uncover the influence of DM in end-stage HF and to ...

Cell recovery from near-death states is a critical yet poorly understood aspect of cell biology. Here, we describe a tightly-regulated programmed cell revival process after exposure of cells to cell ...

imageimageThe crosstalk between Drosophila hemocytes and epithelial tumors remains incompletely understood. This study reveals that hemocytes promote malignant transformation through a bidirectional ...

The E3 ubiquitin ligase SRAS1.1 regulates plant drought resistance by integrating the ubiquitin-proteasome system and autophagy. SRAS1.1 promotes the degradation of the autophagy receptor DSK2A, ...

imageimageThis study reveals the necessity of biallelic functional Kif11 for bipolar spindle assembly in acentrosomal oocytes and a spatially differential requirement for homologous chromosome ...

Defense-associated reverse transcriptase (DRT) systems are implicated in prokaryotic resistance to viral infections, yet the molecular mechanisms underlying their functionality remain largely unknown.

Essentiality studies have traditionally focused on coding regions, often overlooking other small genetic regulatory elements. To address this, we combined transposon libraries containing promoter or ...

Hemocytes facilitate interclonal cooperation-induced tumor malignancy by hijacking the innate immune system in Drosophila ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The bacterial cell wall is primarily composed ...

imageimageIn mouse spermatocytes, the X and Y chromosomes undergo rapid non-homologous synapsis and desynapsis during early pachynema. This study reveals that X-Y desynapsis initiated by the atypical ...