Mykel Williams is feared to have suffered a potential season-ending injury in San Francisco's win over the Giants.

A mind-boggling stat highlights the San Francisco 49ers’ brutal injury luck under coach Kyle Shanahan since 2017.

The San Francisco 49ers and New York Giants met on Sunday afternoon at MetLife Stadium. Here were some of the best plays from San Francisco's win.

NFL insider expects 49ers to stay active in trade market after Keion White deal originally appeared on The Sporting News. Add ...

A big domino falls for the Patriots ahead of the trade deadline with the team reportedly trading defensive end Keion White to ...

The San Francisco 49ers made some big moves this offseason, but they weren't expected to be 5-2 through the first seven weeks ...

The New York Giants play host to the San Francisco 49ers on Sunday in a battle of teams missing multiple star players on both sides of the ball.

Not long after nearly losing a fumble on a sack, Mac Jones finally unravels for the 49ers, tossing a deep pick to Jamel Dean ...

Down 16-0, the 49ers came alive with last-minute theatrics before halftime, highlighted by Kittle’s 17-yard, third-down ...

Long known as a great schemer, Shanahan has pressed all the right buttons elsewhere, helping his team overcome a mountain of ...

Mayfield played without receivers Mike Evans, Chris Godwin and Jalen McMillan, running back Bucky Irving and offensive tackle ...

The San Francisco 49ers have had some bad luck with injuries in their front seven, and they may have lost another defender against the Houston Texans.