Meteorologists said there was a chance the winds would be as severe as those that fueled the Palisades and Eaton fires, but that different locations would likely be affected.
The National Weather Service issued a Red Flag Warning starting Monday for San Diego County's inland valleys and mountains.
The ferocious Santa Ana winds that helped fuel the deadly wildfires around Los Angeles are forecast to ease later Wednesday, but they may return.
With the strongest gusts expected on Tuesday, extreme fire condition threats will prevail until midweek, L.A.-area fire chiefs say.
A "Particularly Dangerous Situation" warning remains in effect as strong winds cause extreme fire danger in Southern California.
Southern California will experience cooler and breezy temperatures over the weekend before another Santa Ana event develops early next week.
Another wave of Santa Ana winds arrive Saturday, likely generating gusts over 40 mph throughout the Inland Empire going into Sunday.
National Weather Service offices across Southern California are warning residents of an increase in weather conditions that are conducive to rapid fire growth. Meteorologists are most concerned about conditions from Monday afternoon through Wednesday morning when winds will be at their peak and relative humidity will be low.
After a brief break on Sunday afternoon, another prolonged round of gusty Santa Ana winds is expected to develop, forecasters say.
Things will remain relatively calm for the weekend, but "a difficult to resolve weather pattern" begins early to mid-next week, the NWS said.
The winds fueling Southern California wildfires form when a high-pressure system develops over the Great Basin in Utah and Nevada
As wildfires rage near Los Angeles, claiming lives and homes, residents cling to hope for a wind shift. With damages projected to reach up to $275 billion, the devastation is immense, but a change in weather may offer a glimmer of relief amidst the chaos.