Itachi Uchiha, one of the most divisive characters in Naruto, had a terminal illness that took his life, but what disease could it have been?

Naruto is one of the most impactful shonen anime and manga series ever to be adapted by Masashi Kishimoto and is remembered due to its rich themes, complex characters, and emotional storytelling.

For starters, Itachi murdered their parents in cold blood. The Uchiha was coerced into doing so, but even then, annihilating the entire clan, including his parents, was in no way a smart move.