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A model of the genome is described which relates certain observations on the additive nature of enzyme activity to observations on the quantitative genetics of fitness traits. The model assumes that ...
When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system. Enzymes usually clear these nucleic acids before they cause an issue, but when these ...
Membrane-associated proteins play a vital role in a variety of cellular processes, yet little is known about the membrane-association mechanism. Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) is ...
All living things are made of carbon, and sugars, e.g. glucose, are a very common source of it. Consequently, most cells are good at eating sugars, using enzymes to digest them through a series of ...
This is a preview. Log in through your library . Abstract The enzymatic latch hypothesis proposes that oxygen (O₂) limitation promotes wetland carbon (C) storage by indirectly decreasing the ...
The muscle destruction associated with Duchenne muscular dystrophy (DMD), the most common childhood form of muscular dystrophy, is halted in mice when supplemental amounts of a naturally occurring ...
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Simultaneously targeting lysosomal enzyme and KRAS-MAPK pathway eradicates pancreatic tumors in preclinical models
Pancreatic cancer is a leading cause of cancer-related death, with a five-year survival rate of 13%. The high mortality is largely due to a lack of effective therapy options. In a recent paper ...
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