Our findings contribute to developing the codon-optimization method in DNA vaccines, and further study is needed to determine a specific correlation between the codon usage patterns and the ...

In this study, researchers established an RNA codon expansion (RCE) platform to assign pseudouridine (Ψ)-modified RNA codons (ΨCodons: ΨGA, ΨAA, ΨAG) as novel "blank" codons for non-canonical ...

In this study, researchers established an RNA codon expansion (RCE) platform to assign pseudouridine (Ψ)-modified RNA codons (ΨCodons: ΨGA, ΨAA, ΨAG) as novel “blank” codons for non ...

A glimpse into nature's looking glass -- to find the genetic code is reassigned: Stop codon varies widely Date: May 22, 2014 Source: DOE/Joint Genome Institute Summary: It has long been assumed ...

Schematic illustration of the RNA codon expansion strategy. This approach consists of two core processes—encoding and decoding—to enable the specific incorporation of non-canonical amino acids.

Upon reaching the stop codon, the ribosome ceases translation and releases the mRNA and newly generated polypeptide. Messenger RNA (mRNA) mRNA is used to convey information from DNA to the ribosome.

Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs).