In an experiment comparing the effects of five different drugs, each drug is tested on a number of different subjects. The outcome of each experiment is the presence or absence of a positive response ...

This example analyzes the data from Beitler and Landis (1985), which represent results from a multi-center clinical trial investigating the effectiveness of two topical cream treatments (active drug, ...

Biometrika is primarily a journal of statistics in which emphasis is placed on papers containing original theoretical contributions of direct or potential value in applications. From time to time, ...

The problem of making inferences about the point in a sequence of zero-one variables at which the binomial parameter changes is considered. The asymptotic distribution of the maximum likelihood ...