Experts weigh in on the use of real-world evidence (RWE) in pain research, providing recommendations for rigorous study design, analysis, and reporting to ensure data validity and credibility.

SAN DIEGO, CA—Does the use of a primary composite endpoint help or harm when it comes to interpreting modern-day clinical trials? Do softer clinical endpoints, such as recurrent angina, restenosis, or ...

Developing treatments for rare diseases poses many unique challenges that cannot be addressed by traditional study designs. Small populations will result in prolonged enrolment periods and/or ...

We performed a systematic review of articles published during a 2-year period in 4 journals in the field of infectious diseases to determine the extent to which the quasi-experimental study design is ...

Noninferiority clinical trials have become a major tool for the evaluation of drugs, devices, biologics, and other medical treatments. Treatment with placebo or with a no-treatment control in a study ...

Once you have determined your research question, the next step is to decide on a research design. As random assignment tends to be challenging in SoTL, most projects tend to fall into the ...

Dose-finding trials are essential to drug development as they establish recommended doses for later-phase testing. We aim to motivate wider use of model-based designs for dose finding, such as the ...

Observational studies are emerging as fundamental sources of information about vaccine effectiveness outside the controlled environment of randomized trials, and they are being used to generate ...

This is a preview. Log in through your library . Abstract In a traditional regression-discontinuity design (RDD), units are assigned to treatment on the basis of a cutoff score and a continuous ...