Accurate prediction of thermodynamic solubility by machine learning remains a challenge. Recent models often display good performances, but their reliability may be deceiving when used prospectively.

The current research aimed to study and measure the solubility of omeprazole (used to treat and reduce stomach acid) for the first time in pure subcritical and ethanol-modified water. These tests have ...

Early adoption of the right approach to address solubility can deliver significant benefits. Currently, a significant proportion of drugs that are approved or in the development pipeline are poorly ...