Maturation of pre-mRNA by capping, splicing, and cleavage and polyadenylation can occur co-transcriptionally at the gene; the substrate for these reactions is therefore a growing nascent RNA chain ...

Alternative polyadenylation, along with alternative splicing and alternative transcription, allows a single gene to produce multiple gene products. Approximately one third of all genes make use of ...

In addition to being dependent on transcription, the capping, splicing and polyadenylation reactions can also influence one another 3, 4 as well as aspects of the transcription process itself 5.

Alternative splicing and alternative polyadenylation also generates variability within mRNA untranslated regions and affects gene expression by adding or removing cis -acting elements that regulate ...

The Lai lab uses an integrated approach to study selected topics in mRNA processing and modification, including alternative polyadenylation, circularization and RNA methylation.

Indeed, >25 coupled reactions, often reciprocal, have been documented among such steps as transcription, capping, splicing, and polyadenylation. Coupling is usually not essential for gene expression, ...

They see to the transcripts’ proper splicing, capping, polyadenylation, and export from the nucleus, and they send the finished RNAs off to sometimes far-flung locales such as axonal terminals for ...