Korea Institute of Science and Technology has described nuclear factor erythroid 2-related factor 2 (NFE2L2; NRF2) activators acting as nitric oxide (NO) production inhibitors and antioxidants ...

NRF2 is just one of thousands of critical proteins in the cell, but it is one that we now know a lot about. Once any molecule achieves a certain level of celebrity status, it tends to acquire a ...

Alpha-fetoprotein up-regulated the expression of c-Src in hepatoma cells is PTEN/AKT signaling pathway dependent or independent. Background: We previously demonstrated that transcription factor Nrf2 ...

This new article publication from Acta Pharmaceutica Sinica B, discusses the efficacy of targeting the Keap1 system through the homoPROTAC-ing technology as an innovative and promising treatment ...

Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leading to pulmonary and extra-pulmonary manifestations due to ...

Researchers have discovered that the transcription factor NRF2 plays a major role in herpes infection and thus is an effective target for restricting viral infection. The herpes simplex virus (HSV) is ...

After a nine-year run, AbbVie is calling it quits on its Reata Pharmaceuticals partnership. The Big Pharma, which ponied up more than $800 million for the rights to a set of Nrf2 activators for kidney ...