The 49ers have now lost both of their starting defensive ends for the season after Nick Bosa previously tore his ACL in Week 3. On top of Bosa and Williams being out for the year,

With Nick Bosa sidelined, the 49ers are predicted to trade for a four-time Pro Bowler to strengthen the pass rush. The 49ers struggle with pass rush due to major injuries, including Nick Bosa's torn ACL.

The Niners were fresh off a roster revamp, saying goodbye to nearly 20 players in the offseason, 15 of whom landed deals elsewhere worth up to a maximum of $341.5 million. In their place, the 49ers leaned into their youth, with an 11-man draft class and a free agent group that had no marquee players.

In spite of Bosa's absence for the rest of the year, as well as starting quarterback Brock Purdy and star tight end George Kittle still potentially sidelined for multiple weeks with injuries of their own, the 49ers are 3-0 and sit alone atop the NFC West. Every other team in the division is currently 2-1.

The Cleveland Browns and Tennessee Titans are rumored to have players available who could be of interest to the Dallas Cowboys, Detroit Lions, San Francisco 49ers and Denver Broncos.

After landing Keion White, the 49ers are expected to keep dealing, with ESPN reporting San Francisco is calling around for more help.

Amid a 4-1 start to the season despite having a roster decimated by injuries, including losing Nick Bosa to a torn ACL, the San Francisco 49ers could pursue a star-level pass-rusher prior to the trade deadline.

As ESPN did a trade primer for every team, Schatz chose left guard as the key position of need for the 49ers. Left guard Connor Colby, a seventh-round rookie, ranks last among all qualified guards in pass block win rate (84.3%)

The 49ers have been besieged by injuries for a second season in a row, and they desperately need more healthy bodies.