Everything you need to know about the MLB matchup between the Houston Astros and the Seattle Mariners, including how to watch and team news.

The Seattle Mariners face the Houston Astros in a regular season MLB game on Sunday, Sept. 21, 2025 (9/21/25) at Daikin Park in Houston, Texas.

After nearly six months of daily play, the final week of Major League Baseball's regular season has arrived. It's shaping up to be a compelling few days, too, with four division titles yet to be decided and 20 teams -- or two-thirds of the league -- still alive in some capacity or another.

Red Sox prospect Johanfran Garcia homered in Salt River’s 5-4 loss to Scottsdale in an Arizona Fall League game on Friday.

Suárez, a 34-year-old trade-deadline acquisition in his second stint with the Mariners, launched a go-ahead grand slam in Game 5 of the ALCS on Friday, lifting the Seattle Mariners to a 6-2 win over the Toronto Blue Jays and a 3-2 advantage in the series.

Derek Jeter, Alex Rodriguez and David Ortiz reacted to the Los Angeles Dodgers' 5-1 win over the Toronto Blue Jays in Game 2 of the World Series. They also discussed the historic performance of Dodgers' pitcher Yoshinobu Yamamoto and previewed Game 3.