Preview the Week 9 NCAA football matchup between the Iowa State Cyclones and BYU Cougars with a prediction, pick, odds and more.

BYU vs. Iowa State predictions and college football picks for Saturday, October 25. LJ Martin and the Cougars grind out a cover in Iowa.

Iowa State is a 2.5-point favorite, according to FanDuel Sportsbook. The total is set at 49.5 points. You can watch KCCI's college football show, "Big College Kickoff," live on Very Local at 10:30 a.m. every Saturday through Nov. 29.

Big 12 foes match up when the Iowa State Cyclones (5-2) and the No. 10 BYU Cougars (7-0) play on Saturday, October 25, 2025 at Jack Trice Stadium. In their most recent outing, the Cyclones lost 24-17 to the Colorado Buffaloes. The Cougars' last game was a 24-21 win over the Utah Utes.

The Iowa State Cyclones are heading into their most important game of the 2025 college football season on Saturday afternoon. They will be hosting the BYU Couga

Our writers pick the entire Big 12 slate straight-up as well as the biggest games for Week 9 of the 2025 college football season.

The University of Iowa Hawkeyes will have a chance to beat Iowa State and Northern Iowa in future football games.

The Iowa State Cyclones will be getting set to host the BYU Cougars in what will likely be the most important game of their season. With a slim chance of making

Chad Leistikow provides analysis about the emotional letdown possibilities and answers 3 text-group questions ahead of Iowa football vs Minnesota.

College football Week 9 odds, picks, predictions, TV channel, streaming for BYU Cougars at Iowa State Cyclones game on Saturday, Oct. 25, 2025.

Here are three takeaways from Iowa State football coach Matt Campbell's media availability ahead of the Cyclones' matchup against BYU.