The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

Heart muscle excitation-contraction (E-C) coupling is governed by Ca²⁺ release units (CRUs) whereby Ca²⁺ influx via L-type Ca²⁺ channels (Cav1.2) triggers Ca²⁺ release from juxtaposed Ca²⁺ release ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 12 (Jun. 5, 2001), pp. 6935-6940 (6 pages) To investigate the molecular basis of the voltage sensor that ...

EXCITATION-CONTRACTION (E-C) coupling in skeletal muscle is a series of events leading from membrane depolarization to the production of tension 1. One of the more important intermediary processes is ...