Completing DNA replication triggers genomic instability in bacteria

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...
Phys.org

DNA replication in early embryos differs from previous assumptions, study shows

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...
Nature

Super-resolved analysis of colocalization between replication and transcription along the cell cycle in a model of oncogene activation

To understand how oncogenes affect genome organization, it is essential to visualize fundamental processes such as DNA replication and transcription at high resolution in intact cells. At the same ...
Nature

CIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to resolve replication stress-induced DNA lesions

DNA replication is a vital process in all biological systems. To faithfully duplicate the entire genome, DNA replication adheres to a strict temporal and spatial program 1. Even under physiological ...