T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

A new cellular atlas charts, in unprecedented detail, how human B cells are built step by step — and offers a window into how this developmental process goes awry in leukemia. The KAUST-led ...

The development of humans and other animals unfolds gradually over time, with cells taking on specific roles and functions via a process called cell fate determination. The fate of individual cells, ...

Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four ...

In the rapidly evolving field of drug discovery, single-cell analysis has become an invaluable tool for understanding cellular heterogeneity and molecular pathways. However, traditional single-cell ...

A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life. Each of us starts ...