Alzheimer’s disease (AD) is characterised by progressive cognitive decline, synaptic loss and neuroinflammation. Central to these processes is the cholinergic system, in which nicotinic acetylcholine ...

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand‐gated ion channels widely expressed in the central and peripheral nervous systems. Subtypes such as homomeric α7 and heteromeric α4β2 ...

Acetylcholine (ACh) is a neuromodulator with a central role in aversive learning - rapid conditioning to unpleasant smell, taste, or touch. These learning functions play out in cells called D2 ...

Acetylcholine (ACh) is a neuromodulator with a central role in aversive learning—rapid conditioning to unpleasant smell, taste, or touch. These learning functions play out in cells called D2 ...

Patients with Alzheimer's disease (AD) have lower levels of the neuromodulator acetylcholine (ACh) in their brains. Donepezil, an AD drug, increases brain ACh levels and improves AD-associated ...

Researchers have long thought that rewards like food or money encourage learning in the brain by causing the release of the "feel-good" hormone dopamine, known to reinforce storage of new information.

Medications prescribed to boost acetylcholine and suppress the immune system have varying levels of success, leading researchers to believe that myasthenia gravis may be caused by varying underlying ...

In healthy people, binding of the molecule acetylcholine (ACh) to its receptor (AChR) on skeletal muscle cells triggers muscle contraction underlying regular daily activities. In the autoimmune ...