Despite an almost complete overhaul of its starting lineup – shuffled as part of the devastating Jayson Tatum Achilles injury – Boston is still a 2-point home favorite in the NBA odds. However, our 76ers vs Celtics predictions and NBA picks have Philadelphia starting its season with a win on Wednesday, October 22.

Preview the Philadelphia 76ers' NBA matchup with Boston, including live stream, TV channel, odds, and game information.

Edgecombe gave the Sixers a three-point lead by converting two free throws with 14.1 seconds left. He went 0 for 2 on his next trip to the foul line, keeping the door open for a Celtics game-winner, but the Sixers got the stop to ensure his fantastic debut was victorious.

But for at least one game, the 76ers will have to wait to deploy their full plan for their roster.

The Philadelphia 76ers secured a crucial opening-night victory against their rival, the Boston Celtics, starting their season on a positive note. The win was powered by stellar play from rising star Tyrese Maxey and an explosive debut from rookie VJ Edgecombe.

Payton Pritchard made things interesting in the finals 16 seconds, making a three and a layup to bring the Celtics to within one. However, he missed two potential game-winning layups in the final three seconds, allowing the 76ers to sneak away with the one-point win.

Preview the Philadelphia 76ers' NBA matchup with Charlotte, including live stream, TV channel, odds, and game information.