Brock Purdy replied in kind after Philip Rivers opened the scoring with a TD pass against the 49ers. Purdy responded with 2!

Fans can listen to Monday Night Football live with SiriusXM on channel 88, NFL Radio, for the national broadcast. Team-specific channels are available, with 225 being the Colts and 226 being the 49ers ...

Broadcast and streaming information for the San Francisco 49ers Week 16 'Monday Night Football' matchup against the Indianapolis Colts at Lucas Oil Stadium.

Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 ...

This article was originally published on www.si.com/nfl/49ers/onsi as The underrated unit that can kick off a 49ers Super ...

The San Francisco 49ers are just hours away from kickoff against the Indianapolis Colts at Lucas Oil Stadium and have announced their pregame roster moves. Teams playing on Monday night have until the ...

The San Francisco 49ers are just hours away from kickoff against the Indianapolis Colts at Lucas Oil Stadium and have announced their pregame roster moves. Teams playing on Monday night have until the ...

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to ...

Philip Rivers, who came out of a five-year retirement last week to return at 44 years old, nearly matched Purdy ...

The 49ers' special teams used to be a weakness, but coach Kyle Shanahan credits San Francisco's kick returners for injecting new life into the unit during the 2025 NFL season. Among all NFL teams, the ...

Trent Williams, Malik Mustapha and Ji'Ayir Brown were among the 49ers with standout performances in Indianapolis.

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...