Brian Kelly and the LSU Tigers will hit the road to Memorial Stadium in Week 1 for a Top-10 matchup against Dabo Swinney's Clemson Tigers. As anticipation build

ESPN’s College Football Countdown turned its attention this week to one of the most anticipated openers of the 2025 season: Clemson hosting LSU in Death Valley on August 30. Host Rece Davis sat down with analysts Roddy Jones and EJ Manuel, and the conversation quickly zeroed in on Clemson quarterback Cade Klubnik.

Clemson is a 4-point favorite against LSU, according to the VegasInsider.com consensus betting line. That’s an uptick from the game’s opening point spread (Clemson -2.5). A few sportsbooks, including FanDuel, have Clemson as a 4.5-point favorite.