St. Cloud or Saint Cloud is a city in northern Osceola County, Florida, United States. It is on the southern shore of East Lake Tohopekaliga …St. Cloud or Saint Cloud is a city in northern Osceola County, Florida, United States. It is on the southern shore of East Lake Tohopekaliga in Central Florida, about 26 miles southeast of Orlando. The population was 35,183 in the 2010 census, and 58,964 in the 2020 census. The city is part of the Orlando–Kissimmee–Sanford metropolitan area.